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Absence of MGMT promoter methylation in endometrial cancer
OBJECTIVE: O(6) –methylguanine-DNA methyltransferase (MGMT) acts to repair DNA damaged by alkylation of guanine residues. MGMT promoter methylation and gene silencing is seen in a variety of cancers and pre-cancerous changes [1-3]. The loss of MGMT activity and promoter methylation is associated wit...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2949277/ https://ncbi.nlm.nih.gov/pubmed/18973931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2008.08.038 |
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