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Absence of MGMT promoter methylation in endometrial cancer
OBJECTIVE: O(6) –methylguanine-DNA methyltransferase (MGMT) acts to repair DNA damaged by alkylation of guanine residues. MGMT promoter methylation and gene silencing is seen in a variety of cancers and pre-cancerous changes [1-3]. The loss of MGMT activity and promoter methylation is associated wit...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2949277/ https://ncbi.nlm.nih.gov/pubmed/18973931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2008.08.038 |
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