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Aberrant Methylation of the X-linked Ribosomal S6 Kinase RPS6KA6 (RSK4) in Endometrial Cancers

PURPOSE: Effective treatments for advanced endometrial cancer are lacking. Novel therapies that target specific pathways hold promise for better treatment outcomes with less toxicity. Mutation activation of the FGFR2/RAS/ERK pathway is important in endometrial tumorigenesis. RPS6KA6 (Rsk4) is a puta...

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Autors principals: Dewdney, Summer B., Rimel, BJ, Thaker, Premal H., Thompson, Dominic M., Schmidt, Amy, Huettner, Phyllis, Mutch, David G., Gao, Feng, Goodfellow, Paul J.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242504/
https://ncbi.nlm.nih.gov/pubmed/21372219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-2668
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