Down-Regulation of Ribosomal S6 kinase RPS6KA6 in Acute Myeloid Leukemia Patients

Objective Signaling pathways such as extracellular regulated kinase/mitogen activated protein kinase (ERK/MAPK) have increased activity in leukemia. Ribosomal 6 kinase (RSK4) is a factor downstream of the MAPK/ERK pathway and an important tumor suppressor which inhibits ERK trafficking. Decrease...

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Main Authors: Rafiee Mohammad, Keramati Mohammad Reza, Ayatollahi Hosein, Sadeghian Mohammad Hadi, Barzegar Mohieddin, Asgharzadeh Ali, Alinejad Mohsen
Formato: Artigo
Idioma:Inglês
Publicado em: Royan Institute (ACECR), Tehran 2016-07-01
Colecção:Cell Journal
Assuntos:
Extracellular Signal-Regulated Kinase
Mitogen Activated Protein Kinase
Ribosomal Protein S6 Kinase
Gene Expression
Acute Myeloid Leukemia
Acesso em linha:http://celljournal.org/web/journal/article/3672/download
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