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Infrequent methylation of the DUSP6 phosphatase in endometrial cancer
OBJECTIVE: Dual-specificity phosphatase six (DUSP6, MKP3, or PYST1) dephosphorylates phosphotyrosine and phosphothreonine residues on ERK-2 (MAPK1) to inactivate the ERK-2 kinase. DUSP6 is a critical regulator of the ERK signaling cascade and has been implicated as a tumor suppressor. DNA methylatio...
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Main Authors: | , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2939303/ https://ncbi.nlm.nih.gov/pubmed/20638106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2010.06.015 |
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