Targeted inhibition of the dual specificity phosphatases DUSP1 and DUSP6 suppress MPNST growth via JNK

PURPOSE: In Neurofibromatosis Type 1 (NF1) and in highly aggressive malignant peripheral nerve sheath tumors (MPNSTs), constitutively active RAS-GTP and increased MAPK signaling are important in tumorigenesis. Dual specificity phosphatases (DUSPs) are negative regulators of MAPK signaling that depho...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Ramkissoon, Annmarie, Chaney, Katherine E., Milewski, David, Williams, Kyle B., Williams, Rory L., Choi, Kwangmin, Miller, Adam, Kalin, Tanya V., Pressey, Joseph G., Szabo, Sara, Azam, Mohammad, Largaespada, David A., Ratner, Nancy
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606396/
https://ncbi.nlm.nih.gov/pubmed/30936125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-3224
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