Targeted inhibition of the dual specificity phosphatases DUSP1 and DUSP6 suppress MPNST growth via JNK

PURPOSE: In Neurofibromatosis Type 1 (NF1) and in highly aggressive malignant peripheral nerve sheath tumors (MPNSTs), constitutively active RAS-GTP and increased MAPK signaling are important in tumorigenesis. Dual specificity phosphatases (DUSPs) are negative regulators of MAPK signaling that depho...

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Detaylı Bibliyografya
Yayımlandı:Clin Cancer Res
Asıl Yazarlar: Ramkissoon, Annmarie, Chaney, Katherine E., Milewski, David, Williams, Kyle B., Williams, Rory L., Choi, Kwangmin, Miller, Adam, Kalin, Tanya V., Pressey, Joseph G., Szabo, Sara, Azam, Mohammad, Largaespada, David A., Ratner, Nancy
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606396/
https://ncbi.nlm.nih.gov/pubmed/30936125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-3224
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