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Highly aneuploid zebrafish malignant peripheral nerve sheath tumors have genetic alterations similar to human cancers

Aneuploidy is a hallmark of human cancers, but most mouse cancer models lack the extensive aneuploidy seen in many human tumors. The zebrafish is becoming an increasingly popular model for studying cancer. Here we report that malignant peripheral nerve sheath tumors (MPNSTs) that arise in zebrafish...

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Hlavní autoři: Zhang, GuangJun, Hoersch, Sebastian, Amsterdam, Adam, Whittaker, Charles A., Lees, Jacqueline A., Hopkins, Nancy
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947874/
https://ncbi.nlm.nih.gov/pubmed/20837522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1011548107
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