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Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass
AIMS/HYPOTHESIS: Prolonged exposure of pancreatic beta cells to excessive levels of glucose and fatty acids, referred to as glucolipotoxicity, is postulated to contribute to impaired glucose homeostasis in patients with type 2 diabetes. However, the relative contribution of defective beta cell funct...
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| Hauptverfasser: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2947580/ https://ncbi.nlm.nih.gov/pubmed/20628728 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-010-1850-5 |
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