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Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass

AIMS/HYPOTHESIS: Prolonged exposure of pancreatic beta cells to excessive levels of glucose and fatty acids, referred to as glucolipotoxicity, is postulated to contribute to impaired glucose homeostasis in patients with type 2 diabetes. However, the relative contribution of defective beta cell funct...

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Detalhes bibliográficos
Main Authors: Fontés, G., Zarrouki, B., Hagman, D. K., Latour, M. G., Semache, M., Roskens, V., Moore, P. C., Prentki, M., Rhodes, C. J., Jetton, T. L., Poitout, V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947580/
https://ncbi.nlm.nih.gov/pubmed/20628728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-010-1850-5
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