Cyclical and Alternating Infusions of Glucose and Intralipid in Rats Inhibit Insulin Gene Expression and Pdx-1 Binding in Islets

OBJECTIVE: Prolonged exposure of isolated islets of Langerhans to elevated levels of fatty acids, in the presence of high glucose, impairs insulin gene expression via a transcriptional mechanism involving nuclear exclusion of pancreas-duodenum homeobox-1 (Pdx-1) and loss of MafA expression. Whether...

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Detalhes bibliográficos
Main Authors: Hagman, Derek K., Latour, Martin G., Chakrabarti, Swarup K., Fontes, Ghislaine, Amyot, Julie, Tremblay, Caroline, Semache, Meriem, Lausier, James A., Roskens, Violet, Mirmira, Raghavendra G., Jetton, Thomas L., Poitout, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2979006/
https://ncbi.nlm.nih.gov/pubmed/17991758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db07-1285
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