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Lack of Preservation of Insulin Gene Expression by a Glucagon-Like Peptide 1 Agonist or a Dipeptidyl Peptidase 4 Inhibitor in an In Vivo Model of Glucolipotoxicity
Prolonged exposure of pancreatic beta-cells to elevated levels of glucose and fatty acids adversely affects insulin secretion and gene expression. AIM: To examine whether the GLP-1 agonist exenatide or the inhibitor of the GLP-1 degrading enzyme dipeptidyl peptidase 4 (DPP-4) sitagliptin rescue insu...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2834862/ https://ncbi.nlm.nih.gov/pubmed/20092903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.diabres.2009.12.020 |
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