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Lack of Preservation of Insulin Gene Expression by a Glucagon-Like Peptide 1 Agonist or a Dipeptidyl Peptidase 4 Inhibitor in an In Vivo Model of Glucolipotoxicity

Prolonged exposure of pancreatic beta-cells to elevated levels of glucose and fatty acids adversely affects insulin secretion and gene expression. AIM: To examine whether the GLP-1 agonist exenatide or the inhibitor of the GLP-1 degrading enzyme dipeptidyl peptidase 4 (DPP-4) sitagliptin rescue insu...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Fontés, Ghislaine, Hagman, Derek K., Latour, Martin G., Semache, Meriem, Poitout, Vincent
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2010
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834862/
https://ncbi.nlm.nih.gov/pubmed/20092903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.diabres.2009.12.020
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