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Pancreatic and duodenal homeobox-1 nuclear localization is regulated by glucose in dispersed rat islets but not in insulin-secreting cell lines
The transcription factor Pancreatic and Duodenal Homeobox-1 (PDX-1) plays a major role in the development and function of pancreatic β−cells and its mutation results in diabetes. In adult β−cells, glucose stimulates transcription of the insulin gene in part by regulating PDX-1 expression, stability...
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| I publikationen: | Islets |
|---|---|
| Huvudupphovsmän: | , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Taylor & Francis
2014
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4588559/ https://ncbi.nlm.nih.gov/pubmed/25437380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/19382014.2014.982376 |
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