Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation

Eitemau Tebyg

• The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome
  gan: Martínez-Barricarte, Rubén, et al.
  Cyhoeddwyd: (2015)
• 3D structure of the C3bB complex provides insights into the activation and regulation of the complement alternative pathway convertase
  gan: Torreira, Eva, et al.
  Cyhoeddwyd: (2009)
• The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity
  gan: Tortajada, Agustín, et al.
  Cyhoeddwyd: (2009)
• Structural basis for the stabilization of the complement alternative pathway C3 convertase by properdin
  gan: Alcorlo, Martín, et al.
  Cyhoeddwyd: (2013)
• Blockade of Alternative Complement Pathway in Dense Deposit Disease
  gan: Berthe-Aucejo, Aurore, et al.
  Cyhoeddwyd: (2014)