The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome

Atypical hemolytic uremic syndrome (aHUS) associates with complement dysregulation caused by mutations and polymorphisms in complement activators and regulators. However, the reasons why some mutations in complement proteins predispose to aHUS are poorly understood. Here, we have investigated the fu...

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Detalhes bibliográficos
Publicado no:Mol Immunol
Main Authors: Martínez-Barricarte, Rubén, Heurich, Meike, López-Perrote, Andrés, Tortajada, Agustin, Pinto, Sheila, López-Trascasa, Margarita, Sánchez-Corral, Pilar, Morgan, B. Paul, Llorca, Oscar, Harris, Claire L., Rodríguez de Córdoba, Santiago
Formato: Artigo
Idioma:Inglês
Publicado em: Pergamon Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4503813/
https://ncbi.nlm.nih.gov/pubmed/25879158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2015.03.248
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