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3D structure of the C3bB complex provides insights into the activation and regulation of the complement alternative pathway convertase
Generation of the alternative pathway C3-convertase, the central amplification enzyme of the complement cascade, initiates by the binding of factor B (fB) to C3b to form the proconvertase, C3bB. C3bB is subsequently cleaved by factor D (fD) at a single site in fB, producing Ba and Bb fragments. Ba d...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2630071/ https://ncbi.nlm.nih.gov/pubmed/19136636 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810860106 |
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