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Structural basis for the stabilization of the complement alternative pathway C3 convertase by properdin
Complement is an essential component of innate immunity. Its activation results in the assembly of unstable protease complexes, denominated C3/C5 convertases, leading to inflammation and lysis. Regulatory proteins inactivate C3/C5 convertases on host surfaces to avoid collateral tissue damage. On pa...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3746899/ https://ncbi.nlm.nih.gov/pubmed/23901101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1309618110 |
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