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Structural basis for the stabilization of the complement alternative pathway C3 convertase by properdin

Complement is an essential component of innate immunity. Its activation results in the assembly of unstable protease complexes, denominated C3/C5 convertases, leading to inflammation and lysis. Regulatory proteins inactivate C3/C5 convertases on host surfaces to avoid collateral tissue damage. On pa...

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Библиографические подробности
Главные авторы: Alcorlo, Martín, Tortajada, Agustín, Rodríguez de Córdoba, Santiago, Llorca, Oscar
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746899/
https://ncbi.nlm.nih.gov/pubmed/23901101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1309618110
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