3D structure of the C3bB complex provides insights into the activation and regulation of the complement alternative pathway convertase

Generation of the alternative pathway C3-convertase, the central amplification enzyme of the complement cascade, initiates by the binding of factor B (fB) to C3b to form the proconvertase, C3bB. C3bB is subsequently cleaved by factor D (fD) at a single site in fB, producing Ba and Bb fragments. Ba d...

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Bibliographic Details
Main Authors: Torreira, Eva, Tortajada, Agustín, Montes, Tamara, de Córdoba, Santiago Rodríguez, Llorca, Oscar
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630071/
https://ncbi.nlm.nih.gov/pubmed/19136636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810860106
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