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Compromized geranylgeranylation of RhoA and Rac1 in mevalonate kinase deficiency
Mevalonate kinase deficiency (MKD) is an autoinflammatory disorder caused by mutations in the MVK gene resulting in decreased activity of the enzyme mevalonate kinase (MK). Although MK is required for biosynthesis of all isoprenoids, in MKD, in particular, the timely synthesis of geranylgeranyl pyro...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Springer Netherlands
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2946549/ https://ncbi.nlm.nih.gov/pubmed/20814828 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10545-010-9173-8 |
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