Unprenylated RhoA Contributes to IL-1β Hypersecretion in Mevalonate Kinase Deficiency Model through Stimulation of Rac1 Activity

Protein prenylation is a post-translational modification whereby non-sterol isoprenoid lipid chains are added, thereby modifying the molecular partners with which proteins interact. The autoinflammatory disease mevalonate kinase deficiency (MKD) is characterized by a severe reduction in protein pren...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: van der Burgh, Robert, Pervolaraki, Kalliopi, Turkenburg, Marjolein, Waterham, Hans R., Frenkel, Joost, Boes, Marianne
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2014
Pynciau:
Immunology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183811/
https://ncbi.nlm.nih.gov/pubmed/25107911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.571810
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