Defects in Mitochondrial Clearance Predispose Human Monocytes to Interleukin-1β Hypersecretion

Most hereditary periodic fever syndromes are mediated by deregulated IL-1β secretion. The generation of mature IL-1β requires two signals: one that induces synthesis of inflammasome components and substrates and a second that activates inflammasomes. The mechanisms that mediate autoinflammation in m...

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Detaylı Bibliyografya
Asıl Yazarlar: van der Burgh, Robert, Nijhuis, Lotte, Pervolaraki, Kalliopi, Compeer, Ewoud B., Jongeneel, Lieneke H., van Gijn, Marielle, Coffer, Paul J., Murphy, Michael P., Mastroberardino, Pier G., Frenkel, Joost, Boes, Marianne
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2014
Konular:
Immunology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931060/
https://ncbi.nlm.nih.gov/pubmed/24356959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.536920
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