Defects in Mitochondrial Clearance Predispose Human Monocytes to Interleukin-1β Hypersecretion

Most hereditary periodic fever syndromes are mediated by deregulated IL-1β secretion. The generation of mature IL-1β requires two signals: one that induces synthesis of inflammasome components and substrates and a second that activates inflammasomes. The mechanisms that mediate autoinflammation in m...

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Detalhes bibliográficos
Main Authors: van der Burgh, Robert, Nijhuis, Lotte, Pervolaraki, Kalliopi, Compeer, Ewoud B., Jongeneel, Lieneke H., van Gijn, Marielle, Coffer, Paul J., Murphy, Michael P., Mastroberardino, Pier G., Frenkel, Joost, Boes, Marianne
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931060/
https://ncbi.nlm.nih.gov/pubmed/24356959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.536920
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