Dysfunctional BLK in common variable immunodeficiency perturbs B-cell proliferation and ability to elicit antigen-specific CD4(+) T-cell help

Common Variable Immunodeficiency (CVID) is the most prevalent primary antibody deficiency, and characterized by defective generation of high-affinity antibodies. Patients have therefore increased risk to recurrent infections of the respiratory and intestinal tract. Development of high-affinity antig...

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Publicat a:Oncotarget
Autors principals: Compeer, Ewoud B., Janssen, Willemijn, van Royen-Kerkhof, Annet, van Gijn, Marielle, van Montfrans, Joris M., Boes, Marianne
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2015
Matèries:
Pathology: Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484417/
https://ncbi.nlm.nih.gov/pubmed/25926555
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