A novel human STAT3 mutation presents with autoimmunity involving Th17 hyperactivation

Mutations in STAT3 have recently been shown to cause autoimmune diseases through increased lymphoproliferation. We describe a novel Pro471Arg STAT3 mutation in a patient with multiple autoimmune diseases, causing hyperactivation of the Th17 pathway. We show that IL-17 production by primary T cells w...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wienke, Judith, Janssen, Willemijn, Scholman, Rianne, Spits, Hilde, van Gijn, Marielle, Boes, Marianne, van Montfrans, Joris, Moes, Nicolette, de Roock, Sytze
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper: Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4652985/
https://ncbi.nlm.nih.gov/pubmed/26343524
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