Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation.

Eitemau Tebyg

• Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras.
  gan: Khosravi-Far, R, et al.
  Cyhoeddwyd: (1994)
• Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation.
  gan: Khosravi-Far, R, et al.
  Cyhoeddwyd: (1996)
• Signaling through mitogen-activated protein kinase and Rac/Rho does not duplicate the effects of activated Ras on skeletal myogenesis.
  gan: Ramocki, M B, et al.
  Cyhoeddwyd: (1997)
• The RhoGEF domain of p210 Bcr-Abl activates RhoA and is required for transformation
  gan: Sahay, S, et al.
  Cyhoeddwyd: (2007)
• The Insert Region of RhoA Is Essential for Rho Kinase Activation and Cellular Transformation
  gan: Zong, Hui, et al.
  Cyhoeddwyd: (2001)