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Compromized geranylgeranylation of RhoA and Rac1 in mevalonate kinase deficiency

Mevalonate kinase deficiency (MKD) is an autoinflammatory disorder caused by mutations in the MVK gene resulting in decreased activity of the enzyme mevalonate kinase (MK). Although MK is required for biosynthesis of all isoprenoids, in MKD, in particular, the timely synthesis of geranylgeranyl pyro...

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Bibliografiset tiedot
Päätekijät: Henneman, L., Schneiders, M. S., Turkenburg, M., Waterham, H. R.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Springer Netherlands 2010
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946549/
https://ncbi.nlm.nih.gov/pubmed/20814828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10545-010-9173-8
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