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Compromized geranylgeranylation of RhoA and Rac1 in mevalonate kinase deficiency

Mevalonate kinase deficiency (MKD) is an autoinflammatory disorder caused by mutations in the MVK gene resulting in decreased activity of the enzyme mevalonate kinase (MK). Although MK is required for biosynthesis of all isoprenoids, in MKD, in particular, the timely synthesis of geranylgeranyl pyro...

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Bibliografische gegevens
Hoofdauteurs: Henneman, L., Schneiders, M. S., Turkenburg, M., Waterham, H. R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer Netherlands 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946549/
https://ncbi.nlm.nih.gov/pubmed/20814828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10545-010-9173-8
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