Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

Although the role of Hedgehog (Hh) signalling in embryonic pattern formation is well established1, its functions in adult tissue renewal and maintenance remain unclear, and the relationship of these functions to cancer development has not been determined. Here we show that the lossof Smoothened (Smo...

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Bibliografiske detaljer
Main Authors: Zhao, Chen, Chen, Alan, Jamieson, Catriona H., Fereshteh, Mark, Abrahamsson, Annelie, Blum, Jordan, Kwon, Hyog Young, Kim, Jynho, Chute, John P., Rizzieri, David, Munchhof, Michael, VanArsdale, Todd, Beachy, Philip A., Reya, Tannishtha
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946231/
https://ncbi.nlm.nih.gov/pubmed/19169242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07737
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