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SVA retrotransposons: Evolution and genetic instability

SINE-VNTR-Alus (SVA) are non-autonomous hominid specific retrotransposons that are associated with disease in humans. SVAs are evolutionarily young and presumably mobilized by the LINE-1 reverse transcriptase in trans. SVAs are currently active and may impact the host through a variety of mechanisms...

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Detalhes bibliográficos
Main Authors: Hancks, Dustin C., Kazazian, Haig
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945828/
https://ncbi.nlm.nih.gov/pubmed/20416380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcancer.2010.04.001
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