Molecular alterations of the IDH1 gene in AML: a Children’s Oncology Group and Southwest Oncology Group study

Recent whole-genome sequencing efforts led to the identification of IDH1(R132) mutations in AML patients. We studied the prevalence and clinical implications of IDH1 genomic alterations in pediatric and adult AML. Diagnostic DNA from 531 AML patients treated on Children’s Oncology Group trial COG-AA...

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Hauptverfasser: Ho, Phoenix A., Alonzo, Todd A., Kopecky, Kenneth J., Miller, Kristen L., Kuhn, Julia, Zeng, Rong, Gerbing, Robert B., Raimondi, Susana C., Hirsch, Betsy A., Oehler, Vivian, Hurwitz, Craig A., Franklin, Janet L., Gamis, Alan S., Petersdorf, Stephen H., Anderson, Jeanne E., Reaman, Gregory H., Baker, Laurence H., Willman, Cheryl L., Bernstein, Irwin D., Radich, Jerald P., Appelbaum, Frederick R., Stirewalt, Derek L., Meshinchi, Soheil
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945692/
https://ncbi.nlm.nih.gov/pubmed/20376086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2010.56
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