Molecular alterations of the IDH1 gene in AML: a Children’s Oncology Group and Southwest Oncology Group study

Recent whole-genome sequencing efforts led to the identification of IDH1(R132) mutations in AML patients. We studied the prevalence and clinical implications of IDH1 genomic alterations in pediatric and adult AML. Diagnostic DNA from 531 AML patients treated on Children’s Oncology Group trial COG-AA...

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Autori principali: Ho, Phoenix A., Alonzo, Todd A., Kopecky, Kenneth J., Miller, Kristen L., Kuhn, Julia, Zeng, Rong, Gerbing, Robert B., Raimondi, Susana C., Hirsch, Betsy A., Oehler, Vivian, Hurwitz, Craig A., Franklin, Janet L., Gamis, Alan S., Petersdorf, Stephen H., Anderson, Jeanne E., Reaman, Gregory H., Baker, Laurence H., Willman, Cheryl L., Bernstein, Irwin D., Radich, Jerald P., Appelbaum, Frederick R., Stirewalt, Derek L., Meshinchi, Soheil
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945692/
https://ncbi.nlm.nih.gov/pubmed/20376086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2010.56
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