Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancer

Epigenetic silencing plays an important role in cancer development. An attractive hypothesis is that local DNA features may participate in differential predisposition to gene hypermethylation. We found that, compared with methylation-resistant genes, methylation-prone genes have a lower frequency of...

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Main Authors: Estécio, Marcos R.H., Gallegos, Juan, Vallot, Céline, Castoro, Ryan J., Chung, Woonbok, Maegawa, Shinji, Oki, Yasuhiro, Kondo, Yutaka, Jelinek, Jaroslav, Shen, Lanlan, Hartung, Helge, Aplan, Peter D., Czerniak, Bogdan A., Liang, Shoudan, Issa, Jean-Pierre J.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2010
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945186/
https://ncbi.nlm.nih.gov/pubmed/20716667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.107318.110
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