Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancer

Epigenetic silencing plays an important role in cancer development. An attractive hypothesis is that local DNA features may participate in differential predisposition to gene hypermethylation. We found that, compared with methylation-resistant genes, methylation-prone genes have a lower frequency of...

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Autors principals: Estécio, Marcos R.H., Gallegos, Juan, Vallot, Céline, Castoro, Ryan J., Chung, Woonbok, Maegawa, Shinji, Oki, Yasuhiro, Kondo, Yutaka, Jelinek, Jaroslav, Shen, Lanlan, Hartung, Helge, Aplan, Peter D., Czerniak, Bogdan A., Liang, Shoudan, Issa, Jean-Pierre J.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2010
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945186/
https://ncbi.nlm.nih.gov/pubmed/20716667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.107318.110
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