GPR54 Regulates ERK1/2 Activity and Hypothalamic Gene Expression in a Gα(q/11) and β-Arrestin-Dependent Manner

G protein-coupled receptor 54 (GPR54) is a G(q/11)-coupled 7 transmembrane-spanning receptor (7TMR). Activation of GPR54 by kisspeptin (Kp) stimulates PIP(2) hydrolysis, Ca(2+) mobilization and ERK1/2 MAPK phosphorylation. Kp and GPR54 are established regulators of the hypothalamic-pituitary-gonadal...

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Bibliographic Details
Main Authors: Szereszewski, Jacob M., Pampillo, Macarena, Ahow, Maryse R., Offermanns, Stefan, Bhattacharya, Moshmi, Babwah, Andy V.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944883/
https://ncbi.nlm.nih.gov/pubmed/20886089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012964
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