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GPR54 Regulates ERK1/2 Activity and Hypothalamic Gene Expression in a Gα(q/11) and β-Arrestin-Dependent Manner
G protein-coupled receptor 54 (GPR54) is a G(q/11)-coupled 7 transmembrane-spanning receptor (7TMR). Activation of GPR54 by kisspeptin (Kp) stimulates PIP(2) hydrolysis, Ca(2+) mobilization and ERK1/2 MAPK phosphorylation. Kp and GPR54 are established regulators of the hypothalamic-pituitary-gonadal...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2944883/ https://ncbi.nlm.nih.gov/pubmed/20886089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012964 |
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