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GnRH Neuron-Specific Ablation of Gα(q/11) Results in Only Partial Inactivation of the Neuroendocrine-Reproductive Axis in Both Male and Female Mice: In Vivo Evidence for Kiss1r-Coupled Gα(q/11)-Independent GnRH Secretion
The gonadotropin-releasing hormone (GnRH) is the master regulator of fertility and kisspeptin (KP) is a potent trigger of GnRH secretion from GnRH neurons. KP signals via KISS1R, a Gα(q/11)-coupled receptor, and mice bearing a global deletion of Kiss1r (Kiss1r(−/−)) or a GnRH neuron-specific deletio...
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Publicado no: | J Neurosci |
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Main Authors: | , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Society for Neuroscience
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4571609/ https://ncbi.nlm.nih.gov/pubmed/26377475 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0041-15.2015 |
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