GnRH Neuron-Specific Ablation of Gα(q/11) Results in Only Partial Inactivation of the Neuroendocrine-Reproductive Axis in Both Male and Female Mice: In Vivo Evidence for Kiss1r-Coupled Gα(q/11)-Independent GnRH Secretion

The gonadotropin-releasing hormone (GnRH) is the master regulator of fertility and kisspeptin (KP) is a potent trigger of GnRH secretion from GnRH neurons. KP signals via KISS1R, a Gα(q/11)-coupled receptor, and mice bearing a global deletion of Kiss1r (Kiss1r(−/−)) or a GnRH neuron-specific deletio...

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Publié dans:J Neurosci
Auteurs principaux: Babwah, Andy V., Navarro, Víctor M., Ahow, Maryse, Pampillo, Macarena, Nash, Connor, Fayazi, Mehri, Calder, Michele, Elbert, Adrienne, Urbanski, Henryk F., Wettschureck, Nina, Offermanns, Stefan, Carroll, Rona S., Bhattacharya, Moshmi, Tobet, Stuart A., Kaiser, Ursula B.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2015
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571609/
https://ncbi.nlm.nih.gov/pubmed/26377475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0041-15.2015
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