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Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation

The constitutive androstane receptor (CAR) and the pregnane × receptor (PXR) are activated by a variety of endogenous and exogenous ligands, such as steroid hormones, bile acids, pharmaceuticals, and environmental, dietary, and occupational chemicals. In turn, they induce phase I–III detoxification...

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Bibliografski detalji
Glavni autori: Hernandez, J.P., Mota, L.C., Baldwin, W.S.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944248/
https://ncbi.nlm.nih.gov/pubmed/20871735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/187569209788654005
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