ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery

Accurate response to replication arrest is crucial to preserve genome stability and requires both the ATR and ATM functions. The Werner syndrome protein (WRN) is implicated in the recovery of stalled replication forks, and although an ATR/ATM-dependent phosphorylation of WRN was observed after repli...

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Bibliographic Details
Main Authors: Ammazzalorso, Francesca, Pirzio, Livia Maria, Bignami, Margherita, Franchitto, Annapaola, Pichierri, Pietro
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944071/
https://ncbi.nlm.nih.gov/pubmed/20802463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.205
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