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The Effect of Thrombin Fragment (TP508) on Myocardial Ischemia Reperfusion Injury in a Model of Type 1 Diabetes

BACKGROUND: We investigated the efficacy of novel thrombin-fragment TP508 on ischemia-reperfusion (IR) injury using a porcine model of type I diabetes. METHODS AND RESULTS: Alloxan-induced diabetic male Yucatan swine underwent 60 minutes of mid-left anterior descending coronary artery occlusion, fol...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chu, Louis M., Osipov, Robert M., Robich, Michael P., Feng, Jun, Sheller, Michael R., Sellke, Frank W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943853/
https://ncbi.nlm.nih.gov/pubmed/20837908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.109.928374
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