Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity.

We have examined cytokine regulation of nitric oxide synthase (NOS) in human umbilical vein endothelial cells (HUVEC). 24-h treatment with IFN-gamma (200 U/ml) plus TNF (200 U/ml) or IL-1 beta (5 U/ml) increased NOS activity in HUVEC lysates, measured as conversion of [14C]L-arginine to [14C]L-citru...

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Pubblicato in:	J Clin Invest
Autori principali:	Rosenkranz-Weiss, P, Sessa, W C, Milstien, S, Kaufman, S, Watson, C A, Pober, J S
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294374/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7514193/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117221
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