Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity.

We have examined cytokine regulation of nitric oxide synthase (NOS) in human umbilical vein endothelial cells (HUVEC). 24-h treatment with IFN-gamma (200 U/ml) plus TNF (200 U/ml) or IL-1 beta (5 U/ml) increased NOS activity in HUVEC lysates, measured as conversion of [14C]L-arginine to [14C]L-citru...

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Detaylı Bibliyografya

Yayımlandı:	J Clin Invest
Asıl Yazarlar:	Rosenkranz-Weiss, P, Sessa, W C, Milstien, S, Kaufman, S, Watson, C A, Pober, J S
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	American Society for Clinical Investigation 1994
Konular:	Research Article
Online Erişim:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294374/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7514193/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117221
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