Metabolic acidosis stimulates muscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes.

Metabolic acidosis often leads to loss of body protein due mainly to accelerated protein breakdown in muscle. To identify which proteolytic pathway is activated, we measured protein degradation in incubated epitrochlearis muscles from acidotic (NH4Cl-treated) and pair-fed rats under conditions that...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Mitch, W E, Medina, R, Grieber, S, May, R C, England, B K, Price, S R, Bailey, J L, Goldberg, A L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294343/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8182144/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117208
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