Metabolic acidosis stimulates muscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes.

Metabolic acidosis often leads to loss of body protein due mainly to accelerated protein breakdown in muscle. To identify which proteolytic pathway is activated, we measured protein degradation in incubated epitrochlearis muscles from acidotic (NH4Cl-treated) and pair-fed rats under conditions that...

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Pubblicato in:	J Clin Invest
Autori principali:	Mitch, W E, Medina, R, Grieber, S, May, R C, England, B K, Price, S R, Bailey, J L, Goldberg, A L
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294343/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8182144/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117208
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