Metabolic acidosis stimulates muscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes.

Metabolic acidosis often leads to loss of body protein due mainly to accelerated protein breakdown in muscle. To identify which proteolytic pathway is activated, we measured protein degradation in incubated epitrochlearis muscles from acidotic (NH4Cl-treated) and pair-fed rats under conditions that...

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Opis bibliograficzny
Wydane w:	J Clin Invest
Główni autorzy:	Mitch, W E, Medina, R, Grieber, S, May, R C, England, B K, Price, S R, Bailey, J L, Goldberg, A L
Format:	Artigo
Język:	Inglês
Wydane:	American Society for Clinical Investigation 1994
Hasła przedmiotowe:	Research Article
Dostęp online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294343/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8182144/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117208
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Metabolic acidosis stimulates muscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes.

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