Metabolic acidosis stimulates muscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes.

Metabolic acidosis often leads to loss of body protein due mainly to accelerated protein breakdown in muscle. To identify which proteolytic pathway is activated, we measured protein degradation in incubated epitrochlearis muscles from acidotic (NH4Cl-treated) and pair-fed rats under conditions that...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Mitch, W E, Medina, R, Grieber, S, May, R C, England, B K, Price, S R, Bailey, J L, Goldberg, A L
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 1994
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294343/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8182144/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117208
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires