PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX

It is accepted that resistance of Plasmodium falciparum to chloroquine (CQ) is caused primarily by mutations in the pfcrt gene. However, a consensus has not yet been reached on the mechanism by which resistance is achieved. CQ-resistant (CQR) parasite lines accumulate less CQ than do CQ-sensitive (C...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Bray, Patrick G., Mungthin, Mathirut, Hastings, Ian M., Biagini, Giancarlo A., Saidu, Dauda K., Lakshmanan, Viswanathan, Johnson, David J., Hughes, Ruth H., Stocks, Paul A., O'Neill, Paul M., Fidock, David A., Warhurst, David C., Ward, Stephen A.
التنسيق: Artigo
اللغة:Inglês
منشور في: 2006
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943415/
https://ncbi.nlm.nih.gov/pubmed/16956382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2006.05368.x
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