Evidence for a Central Role for PfCRT in Conferring Plasmodium falciparum Resistance to Diverse Antimalarial Agents

Chloroquine resistance in Plasmodium falciparum is primarily conferred by mutations in pfcrt. Parasites resistant to chloroquine can display hypersensitivity to other antimalarials; however, the patterns of cross-resistance are complex, and the genetic basis has remained elusive. We show that stepwi...

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Autori principali: Johnson, David J., Fidock, David A., Mungthin, Mathirut, Lakshmanan, Viswanathan, Sidhu, Amar Bir Singh, Bray, Patrick G., Ward, Stephen A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2004
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943419/
https://ncbi.nlm.nih.gov/pubmed/15383277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2004.09.012
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