Glutathione Transport: A New Role for PfCRT in Chloroquine Resistance

Aims: Chloroquine (CQ) kills Plasmodium falciparum by binding heme, preventing its detoxification to hemozoin in the digestive vacuole (DV) of the parasite. CQ resistance (CQR) is associated with mutations in the DV membrane protein P. falciparum chloroquine resistance transporter (PfCRT), mediating...

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Autori principali: Patzewitz, Eva-Maria, Salcedo-Sora, J. Enrique, Wong, Eleanor H., Sethia, Sonal, Stocks, Paul A., Maughan, Spencer C., Murray, James A.H., Krishna, Sanjeev, Bray, Patrick G., Ward, Stephen A., Müller, Sylke
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2013
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Forum Original Research Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739961/
https://ncbi.nlm.nih.gov/pubmed/23256874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2012.4625
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